DHEA
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By dr c golding
MBCHB (cum laude), FCP(SA), ABAARM,FAAFM
Fellow of the college of physicians of south africa
American academy board certified in antiaging medicine
Fellow in antiaging and functional medicine
In response to a recent article stating that there is no evidence that dhea increases libido in women, let us take a closer look at a few studies that actually do prove the contrary…there is plenty science to support the use of dhea .
Dawn study , von muhlen D et al. The dhea and wellness (dawn) study : research design methods. Contemp clin trials . 2006 may 6
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..epidemiological evidences in humans and animal studies suggest that dhea may have cardioprotective, antiobesity, antidiabetic, and immunoenhancing properties
..double blind, placebo controlled
..50mg dhea x 1year men and women 55-85
Baulieu EE et al. DHEA, DHEA s, and aging : contribution of the dheaage study to a sociobiomedical issue. . Proc Natl Acad Sci U S A 2000 Apr 11;97(8):4279-84
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.no “harmful” levels of dheas adverse effects~
..IMPROVED LIBIDO, bone turnover, skin in women but not men
..increase in testosterone and estradiol in women
Morales et al, clin endocrinol , 10/98
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DHEA 100mg . 6 months
..age-advanced men and women
..double blind, placebo controlled, crossover design
..dhea 50mg/day increases IgF1 10% in men and women
..in women, but not in men, serum Androstenedione, testosterone and DHT were
Elevated leading to anincrease in libido
.. men, but not in women, fat body mass decreased and knee muscle strength as well
as lumbar back strength increased
..no significant adverse effects were observed
Jankowski CM et al. Effects od dhea replacement . Therapy on bone mineral density in older adults. A randomized , controlled trial. J Clin Endocrinol metab. 2006 may 30
Dhea 50 mg/d for or placebo for 12 months
Improved hip Bon mineral density in older adults and spine bone mineral density in older women
Summary
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Dhea raises testosterone in women
Usually bot much change in testosterone in men
Increases libido in women
May or may not improve body composition in women
Improves body composition in men
Conflicting data on strength in men
Reverses osteoporosis
Raises igf1
No significant adverse effects
Dhea may be necessary for immune e response
Patients on corticosteroids should have dhea replacement therapy
Autoimmune disease may benefit form dhea replacement
Since aging is a state of cortisol excess, patients with adrenopause should received dhea replenishment therapy
Dhea inhibits Il-6 and chronic inflammation
DHEA IS AN ANTIAGING STEROID
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Antiaging
Based on both in vitro and vivo studies
Stimulates immune system
Anti-diabetes mellitus
Anti-atherosclerosis
Anti-dementia
Anti-obesity
Anti-osteoporosis
Anti-cancer
Above confirmed in : Nawata Het al. Mechanism of action of antiaging dhea-s and the replacement of dhea-s Mech aging dev 2002 apr 2002 apr 30;123(8):1101-6